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Synthetic probiotic could control necrotic enteritis in poultry

The technology is currently seeking approval from the Food and Drug Administration.

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Broilers Feeding Indoors
David Tadevosian I Shutterstock.com

Probiotic biotherapeutics harness the power of synthetic biology and genetic engineering to prevent, combat and control the bacterium Clostridium perfringens, a precursor to necrotic enteritis in poultry.

“Things we can do right now in the lab was science fiction 15 – 20 years ago,” Yiannis Kaznessis, founder and CEO, General Probiotics and AgThera, explained. “The results we’re seeing with our organism are fairly strong and that’s, I think, the power of genetic engineering.”

Necrotic enteritis is an acute infection caused by the bacteria C. perfingens. Intestinal damage in poultry allows the bacteria, which is a normal inhabitant of the intestinal tract, to attach, proliferate and produce toxins.

The probiotic effectively decreases mortality by 40-70% against C. perfringens in animal tests. In addition, birds that were administered the live therapeutic showed improved feed conversion ratio.

At the 2023 Poultry Tech Summit, learn about the development and testing of the recombinant antimicrobial live therapeutic for performance improvements and for prevention and control of necrotic enteritis (NE) associated with Clostridia perfringens in broiler chickens.

The Poultry Tech Summit, scheduled for November 6-8 at the Hilton Atlanta Airport in Atlanta, Georgia, focuses on the transition of innovative technologies into commercial applications to advance the poultry industry.

Registration for this event is now open. Early bird savings are available.

Moving through the FDA approval process

General Probiotics has obtained categorical exclusion claims and food use authorization from the Center for Veterinary Medicine and is working on label claims approval for the biotherapeutic from the Food and Drug Administration (FDA).

“The safety profile of our organisms is of paramount importance to us. This is one of the main reasons why we decided to go down the FDA path,” Kaznessis said. “We’ve been working with the agency for the past three years now to demonstrate the safety of these genetically modified organisms in all aspects of their utility.”

Having a dedicated team is crucial to regulatory success, he noted, adding that “You need to have a core team that will take you through what is a challenging process – from discovering to developing to releasing at commercial scale and marketing,’

Attend the 2023 Poultry Tech Summit

Join an exclusive international gathering of industry-changing innovators, researchers, entrepreneurs, technology experts, investors and leading poultry producers at the 2023 edition of Poultry Tech Summit on November 6-8 at the Hilton Atlanta Airport in Atlanta, Georgia. 

Attendees can expect the same groundbreaking innovation and insightful presentations that made the previous events well-attended with deep dialogue on new prospective solutions and next-generation technologies. Poultry Tech Summit focuses on the transition of innovative technologies into commercial applications to advance the poultry industry.

Registration for this event is now open. Early bird savings are available.

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